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Behaviour change after flea/ worming


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We have a lovely female Labrador, approx 2 1/2 years old. She thrives on routine and needs things to be predictable or becomes very stressed. Has an incredibly high prey drive and loves to train and explore parks and go for walks.


She frequently has 'off' weeks where she is suddenly much more reactive, anxious, unsettled at times and generally not herself. It has taken us some time to work out possible triggers and we have found that her monthly flea/ working medicine seems to be one. Within 12-24 hours her behaviour changes and lasts for 2-3 days. We were using Advocate drops (had some ear mite issues early on and this worked well in our last lab and seemed effective for our girl) but switched to Nexguard spectra last month to see if oral worked better for her - response to this was less clear, possibly bad timing as was just getting over a couple of bad weeks post annual vaccination.

She is due again today, has had a lovely calm few days so will be fairly easy to see if any changes after this. I have read about allergic reactions and she doesn't display these tupe of signs. Vet gave good check over 6weeks ago when vaccinated and said she was in great health.


From a pup she has always been easily overstimulated by touch and seems to be easily effected by any internal sensation (e.g. hunger, tired, needs to use bowels, etc).

We have found we need to closely monitor her weight as even .5kg loss can trigger her and as soon as gains it back she is back to her calmer self.


Would appreciate any suggestions or experiences people can share around behaviour changes with these medicines (or vaccinations as also seem to case some issues)



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Her vet didn't see anything unusual in her past history - the increased sensitivity, etc ? maybe another vet would see things differently. if there are no fleas present - perhaps hold off on medication. Why put her thru that just 'in case? ' If she is so sensitive to chemicals etc , I'd be doing a daily flea-comb instead .... 

4 hours ago, ecpups said:

was just getting over a couple of bad weeks post annual vaccination.

and this, also. This is a concern. the vet wasn't worried that a reaction occurred? they were happy to vaccinate a dog who has bad reactions to chemicals/weight changes? 
I agree with speaking to her breeder, and perhaps consulting a vet who is  expert in maybe immunology/internal medicine ? 

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  • 1 month later...

Bob reacts badly to drontal, these use the same medication as a number of other wormers.


After searching and sifting through ingredients we settled on milpro which seems to do the job and not turn him into a hyper unstoppable destruction machine. 


My advice is to try something else, look at the ingredients and see if you can find something else that should do the same job. 

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